African Journal of Diabetes medicine received 1366 citations as per google scholar report
Commentary
Hyperglycemia-Associated Oxidative Stress in Diabetes
Author(s): Mark Seljan John*
Hyperglycemia refers to a condition during which associate excessive quantity of aldohexose circulates within the plasm. a good vary of proof has tested hyperglycaemia to be an excellent inducer of reactive element species (ROS), through that varied processes and communication transduction cascades area unit activated or stifled. Bursts of ROS are made by mitochondria, NADPH enzyme, and organic compound enzyme underneath hyperglycaemia. These excessive ROS can any cause aerophilous stress and contribute to the event of hyperglycaemia complications. One among the downstream processes suffering from reaction imbalance is autophagy. Increasing proof shows disturbed autophagy in cell lines treated with high aldohexose or in animals underneath hyperglycaemia. The communication pathways concerned in area unit quite moot, however. Here, we have a tendency to specialise in the ROS-ERK/JNK-p53 pa.. Read More»
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